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VIDEO Wikipedia describes Industry 4.0 as follows: “Industry 4.0 is a name for the current trend of automation and data exchange in manufacturing technologies. It includes cyber-physical systems, the Internet of things, cloud computing and cognitive computing.” How does this differ from past trends like Process Analytical Technology (PAT) and Quality by Design (QbD) and how do we as chemometricians contribute to the development of tools for Industry 4.0?